New York Hospital opens Campbell Convalescent Cottages.

Manhattan Maternity and Dispensary opens at 327 East 60th Street.

Cornell University Medical College is established.

Bloomingdale Asylum moves to White Plains.

In March, New York Hospital opens a new building on West 15th and 16th Streets. The New York Hospital Training School for Nurses is established.

New York Hospital opens the House of Relief, a sub-station for emergency care on Chambers Street. The House of Relief later opens a facility on Hudson Street in 1894.

From January to May of 1869, patients are moved to the South Hospital Building (New York Hospital's facility for the seamen). The North House and Main Buildings are demolished. The hospital operates out of the South Hospital Building until February of 1870. The South Hospital is razed and the property is sold.

The New York Infant Asylum is chartered, and opens on 106th Street.

The Nursery for the Children of Poor Women (later called Nursery and Child's Hospital), the first nursery in New York City, opens on St. Mark's Place.

The New York Asylum for Lying-In Women is founded.