Bloomingdale Asylum moves to White Plains.

In March, New York Hospital opens a new building on West 15th and 16th Streets. The New York Hospital Training School for Nurses is established.

New York Hospital opens the House of Relief, a sub-station for emergency care on Chambers Street. The House of Relief later opens a facility on Hudson Street in 1894.

From January to May of 1869, patients are moved to the South Hospital Building (New York Hospital's facility for the seamen). The North House and Main Buildings are demolished. The hospital operates out of the South Hospital Building until February of 1870. The South Hospital is razed and the property is sold.

The New York Infant Asylum is chartered, and opens on 106th Street.

The Nursery for the Children of Poor Women (later called Nursery and Child's Hospital), the first nursery in New York City, opens on St. Mark's Place.

The New York Asylum for Lying-In Women is founded.

New York Hospital continues its care of the mentally ill, by opening the Bloomingdale Asylum in Morningside Heights (later the site of Columbia University).

The Lying-In Hospital of the City of New York, the first to provide obstetrical care for women in New York City, is established. (In the early 1800s, the hospital is affiliated with New York Hospital).

New York Hospital opens to civilians.